A Protocol to Wean From Noninvasive Mechanical Ventilation

Duan jun

Status: Terminated

Conditions: Ventilator Weaning

Treatments: Other: physician's orders; Device: protocol

Study type: Interventional

Funder types: Other

Identifiers

NCT01535755

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Details and patient eligibility

About

The investigators use a protocol to wean from noninvasive mechanical ventilation.

Full description

Design: Prospective, randomized, controlled trial, with 2 groups: study (protocol weaning group) and control (clinicians' order weaning group). Setting: Respiratory Intensive Care Unit (RICU). Subjects: Patients >18 yr, noninvasive mechanical ventilation >24 hours. Interventions and measurements: Study group (weaning as the protocol) and control group (weaning as the clinicians' order); recording of clinical variables at admission and during RICU stay, and end-point variables (noninvasive mechanical ventilation day, RICU and hospital stay, RICU mortality. Expected results: the protocol group's noninvasive mechanical ventilation days is less than clinicians' order group.

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. noninvasive mechanical ventilation > 24 hours.
2. age >18 years

Exclusion criteria

1. severe cerebraI，heart，hepatic and renal faiIure.
2. facial or cranial trauma or surgery.
3. facial abnormalities.
4. recent gastric or esophageal surgery.
5. active upper gastrointestinal bleeding.
6. large amount of sputum with weak cough ability
7. lack of co-operation.

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

protocol group

Active Comparator group

Description:

This group patients are weaned as the protocol which the investigators described.

Treatment:

Device: protocol

clinicians' order group

Other group

Description:

This group patients are weaned as the clinicians' order.

Treatment:

Other: physician's orders