A Radiomic Model for Risk of Local Recurrence and DFS for T3 and T4 Non-small Cell Lung Cancer

Jinling Hospital, China

Status: Completed

Conditions: Lung Cancer, Nonsmall Cell

Treatments: Other: tumor and peritumor radiomic feature

Study type: Observational

Funder types: Other

Identifiers

NCT06405815

JinlingHospital_lungcancer

Details and patient eligibility

About

The investigators retrospectively collected the participants with T3 and T4, N0-2, M0 NSCLC patients resected between January 2013 to December 2021 for training and internal validation. The Clinical data, preoperative laboratory results and images were collected. High-risk margins were defined as R1 or R2 surgical margins or local recurrence during follow-up, and the investigators also collected the disease-free survival time. On the Deepwise multi-modal research platform, the images were semi-automatically segmented and expanded outward by 3mm to obtain the peritumor tissue. PyRadiomics was used to extract the radiomic features. LASSO was used to select the features and tumor radiomics model, peritumor model and combined model were built using 5-fold cross-validation. And it was further tested on the independent cohort. Discrimination was assessed by using the C-index and area under the receiver operating characteristic curve (AUC), sensibility, specificity.

Enrollment: 200 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with T3 and T4 stage NSCLC；
• available preoperative chest CTE within two weeks of surgery

Exclusion criteria

• inadequate imaging quality resulted from breathing artifact;
• without regularly follow-up information on recurrence location and time

Trial design

200 participants in 2 patient groups

high-risk surgical margin

Description:

High-risk margins were defined as R1 or R2 surgical margins or local recurrence during follow-up.

Treatment:

Other: tumor and peritumor radiomic feature

Low-risk surgical margin

Description:

Low-risk margins were defined as R0 surgical margin meanwhile arising distant metastasis during follow-up.

Treatment:

Other: tumor and peritumor radiomic feature