A Randomised Comparison of Left and Right Sided Approaches to Ablation of the Atrioventricular Junction

East Sussex Hospitals NHS Trust

Status: Unknown

Conditions: Atrial Fibrillation

Treatments: Procedure: atrioventricular node ablation

Study type: Interventional

Funder types: Other

Identifiers

NCT05211453

S001

Details and patient eligibility

About

This study will compare right sided atrioventricular node ablation to left sided atrioventricular node ablation

Full description

Right-sided atrioventricular node ablation has been the initial conventional approach however up to 18.5% of patients require switching to a left sided approach or have a challenging procedure. Previous studies have found that left sided ablation is more efficacious than right-sided ablation requiring less than 5 applications of radiofrequency energy to induce atrioventricular block.

This study will compare right sided atrioventricular node ablation to left sided atrioventricular node ablation

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age greater than or equal to 18 years
• Referred for atrioventricular node ablation for any such indication

Exclusion criteria

• Stroke or transient ischaemic attack (TIA) within 6 months
• Myocardial infarction within 6 months
• Medical conditions limiting expected survival to <1 year
• Moderate to severe aortic stenosis
• History of aortic or mitral valve replacement
• Pregnancy or breast feeding women

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Right sided atrioventricular node ablation

Active Comparator group

Description:

Right sided atrioventricular node ablation

Treatment:

Procedure: atrioventricular node ablation

Left sided atrioventricular node ablation

Active Comparator group

Description:

Left sided atrioventricular node ablation

Treatment:

Procedure: atrioventricular node ablation