A Randomized Control Trial of Narrative Exposure Therapy Versus Treatment as Usual in the Therapy of Borderline Personality Disorder (NET)

Z

Zentrum für Integrative Psychiatrie

Status

Unknown

Conditions

Borderline Personality Disorders
Posttraumatic Stress Disorders

Treatments

Behavioral: narrative exposure therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT01033708
NET

Details and patient eligibility

About

Definition of the efficacy of NET compared with "treatment as usual" in the treatment of patients with complex traumatic disease (borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD)) as assessed by structured clinical interviews. Furthermore, to evaluate the sleep, cortisol level and epigenetic differences in the process of the specific therapy compared to treatment as usual.

Full description

Experimental intervention: Narrative Exposure Therapy (NET), an evidence-based trauma-focussed treatment, suitable for survivors of prolonged and repeated exposure to traumatic stress and childhood adversity. Control intervention: Treatment as usual. Follow-up per patient: 3 follow-up assessments- 4 weeks, 6 months,12 months and 24 months after end of experimental/ control intervention Duration of intervention per patient: Both treatment types will be conducted for 10-14 sessions of 60-90 min in length. Additionally 5 sleep laboratory investigations (1 pre- and 4 post- intervention (4 weeks, 6 months, 12 months, 24 months after treatment)) will be carried out. Additionally the cortisol level in the hair and epigenetic markers will be recorded. The estimated observation time is 2 years.

Enrollment

80 estimated patients

Sex

All

Ages

18 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • DSM-IV -TR Diagnosis axis II: borderline personality disorder; axis I: posttraumatic stress disorder
  • stable medication
  • age 18-45 years, gender female
  • legal competence
  • sufficient cognitive function
  • sufficient knowledge of the German or English language

Exclusion criteria

Known severe internal, neurological, musculoskeletal, endocrinological or sleep disorders with organic origin (clinical examination during the screening visit, judged by the investigator)

  • gravidity (positive ß-HCG test)
  • continuing and not interruptible exposure to sexual or physical abuse
  • acute suicidal tendency
  • positive drug-screening in urine toxicology test

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

80 participants in 2 patient groups

treatment as usual
Active Comparator group
Description:
Treatment as usual
Treatment:
Behavioral: narrative exposure therapy
narrative exposure therapy
Experimental group
Description:
Narrative Exposure Therapy (NET), an evidence-based trauma-focussed treatment, suitable for survivors of prolonged and repeated exposure to traumatic stress and childhood adversities
Treatment:
Behavioral: narrative exposure therapy

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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