A Randomized Controlled Trial Comparing Two Timing Regimens of Pico-salax for Colon Cleansing Prior to Colonoscopy

Queen's University

Status and phase: Completed; Phase 4

Conditions: Colonoscopy

Treatments: Drug: Split Dose Pico-Salax; Drug: Pico-Salax

Study type: Interventional

Funder types: Other

Identifiers

NCT00885274

Hookey Pico-Salax Timing

Details and patient eligibility

About

Pico-Salax is an osmotic and stimulant bowel cleansing agent used prior to colonoscopy. It is unknown whether splitting the doses (i.e. taking the second dose the morning of the colonoscopy) results in a better bowel cleansing, as research with other agents suggests this may be the case. This study aims to assess whether splitting the dose of Pico-Salax results in a better bowel cleansing than traditional dosing.

Enrollment: 250 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• colonoscopy indicated

Exclusion criteria

• congestive heart failure
• ascites
• renal failure
• hyponatremia
• previous intestinal surgery

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

250 participants in 2 patient groups

Split Dose

Experimental group

Description:

Doses of Pico-Salax split: one dose administered the night prior to colonoscopy and the other dose administered the day of the procedure.

Treatment:

Drug: Split Dose Pico-Salax

Traditional Dose

Active Comparator group

Description:

Both doses of Pico-Salax taken the evening prior to colonoscopy.

Treatment:

Drug: Pico-Salax