Comparing the Effects of Commercially Available Dietary Supplements on CoQ10 Concentrations

OvationLab

Status and phase: Active, not recruiting; Phase 3; Phase 2

Conditions: Health; Wellness

Treatments: Dietary Supplement: Ubiquinone; Other: Placebo; Dietary Supplement: Geranylgeraniol; Dietary Supplement: Ubiquinol + geranylgeraniol; Dietary Supplement: Ubiquinol

Study type: Interventional

Funder types: NETWORK

Identifiers

NCT06640465

OvationLab

Details and patient eligibility

About

The primary purpose of this study is to compare the safety and effectiveness of commercially available dietary supplements believed to increase coenzyme Q10 (CoQ10) concentrations.

An 8-week, randomized, placebo-controlled clinical trial will be conducted comparing the effectiveness of four commercially available dietary supplements on increasing CoQ10 concentrations and self-reported health outcomes.

Enrollment: 150 patients

Sex: All

Ages: 40+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Adult males or females age ≥ 40 years
2. Ability to read and speak English

Exclusion criteria

1. Daily use within the past 2 months of any dietary supplements containing CoQ10 or geranylgeraniol (GG)
2. Taking a statin medication within the past 6 months
3. Current daily usage of H2 blockers or PPI medications
4. Current daily use of bisphosphonates
5. Current daily tobacco smoker
6. Known allergies to any substance in the study products
7. Currently pregnant or lactating women or women planning to become pregnant in the next 12 weeks
8. Current diagnosis of a chronic health condition (e.g., cancer, Crohn's disease) deemed clinically contraindicated for the study protocol.
9. Participant in a clinical trial in the previous 30 days.
10. Participants unable to provide consent

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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150 participants in 5 patient groups, including a placebo group

Ubiquinol + geranylgeraniol combination (Designs for Health - CoQnol™ 200)

Experimental group

Treatment:

Dietary Supplement: Ubiquinol + geranylgeraniol

Geranylgeraniol (Annatto-GG™ 300)

Experimental group

Treatment:

Dietary Supplement: Geranylgeraniol

Ubiquinol (Jarrow Formulas QH-absorb® 200 mg)

Experimental group

Treatment:

Dietary Supplement: Ubiquinol

Ubiquinone (NOW CoQ10 200mg)

Experimental group

Treatment:

Dietary Supplement: Ubiquinone

Placebo

Placebo Comparator group

Treatment:

Other: Placebo