A Real-World Study on Ultrasound-Based Screening and Integrated Therapeutic Strategies for Patients With Concomitant Coronary and Cervicocephalic Artery Stenosis (ANGEL-UNIFY)

Capital Medical University

Status: Enrolling

Conditions: Coronary Artery Disease; Carotid Artery Stenosis; Cerebrovascular Disorders

Treatments: Procedure: Percutaneous Coronary Intervention; Procedure: Cerebrovascular Intervention (CAS ）; Other: No Intervention / Observation

Study type: Observational

Funder types: Other

Identifiers

NCT07034157

KS2025006

Details and patient eligibility

About

This prospective observational cohort study aims to investigate the prevalence and clinical significance of head and neck arterial stenosis in patients with coronary artery disease (CAD) undergoing or scheduled for percutaneous coronary intervention (PCI). Using Doppler ultrasound as the primary screening tool, the study will assess the degree of stenosis and evaluate the impact of different combined treatment strategies on patient outcomes. The research will provide real-world evidence to optimize integrated care approaches for patients with comorbid cardiovascular and cerebrovascular diseases.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age ≥18 years;
2. Patients with coronary artery disease scheduled to undergo elective percutaneous coronary intervention (PCI) on the following day.

Exclusion criteria

1. The expected survival is less than 1 years;
2. Simultaneously merge other serious diseases;

Trial design

1,000 participants in 3 patient groups

Group 1: PCI + Carotid Revascularization

Description:

Patients diagnosed with both coronary artery disease and significant carotid artery stenosis requiring intervention, who received both PCI and carotid revascularization.

Treatment:

Procedure: Cerebrovascular Intervention (CAS ）

Procedure: Percutaneous Coronary Intervention

Group 2: PCI + Observation of Carotid Stenosis

Description:

Patients who underwent PCI for coronary artery disease, with no carotid stenosis or with carotid stenosis not requiring or not receiving interventional treatment.

Treatment:

Other: No Intervention / Observation

Procedure: Percutaneous Coronary Intervention

Group 3: Observation Only (No PCI + No CAS)

Description:

Patients who did not undergo PCI and either had no carotid artery stenosis or were managed medically for carotid stenosis without any revascularization.

Treatment:

Other: No Intervention / Observation