A Reduced 11-b-HSD Activity, a Novel Mechanism of Salt Sensitivity and Hypertension After Renal Allograft Donation?

Insel Gruppe AG, University Hospital Bern

Status: Completed

Conditions: Renal Failure; Living Donors; Renal Transplantation

Treatments: Dietary Supplement: Low and high salt diets

Study type: Interventional

Funder types: Other

Identifiers

NCT01009229

Uehlinger-001

Details and patient eligibility

About

Consecutive living-kidney donor candidates (n=100) will be recruited after being accepted for donation according to official guidelines. An assessment of salt sensitivity, 11 beta HSD activity, 24 hour blood pressure, urine collection and physical exam will be performed prior nephrectomy and 14, 52, 156, 208 days post-nephrectomy.

Full description

Consecutive living-kidney donor candidates (n=100) will be recruited after being accepted for donation. The assessment of salt sensitivity, 11 beta HSD activity, 24 hour blood pressure, urine collection and physical exam will be performed prior nephrectomy and 14, 52, 156, 208 days post-nephrectomy.

Enrollment: 100 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acceptance for living kidney donation

Exclusion criteria

• withdrawal of consent

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

1

Other group

Treatment:

Dietary Supplement: Low and high salt diets