A Registered Cohort Study on Brain Calcification

Wan-Jin Chen

Status: Enrolling

Conditions: Brain Calcification

Study type: Observational

Funder types: Other

Identifiers

NCT04010201

MRCTA,ECFAH of FMU [2019]198

Details and patient eligibility

About

Brain calcification is a common neuroimaging feature in patients with metabolic, neurological, or developmental disorders, infectious diseases, traumatic or toxic history, as well as in otherwise normal older people. To understand the clinical and genetic characteristics of brain calcification, we establish a cohort of brain calcification to follow up patients with brain calcification.

Enrollment: 2,000 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with brain calcium deposit(s) based on examinations of CT scans
• Patients with total calcification score(TCS) greater than the physiological threshold
• Relatives of brain calcification patients.
• Unrelated healthy controls
• Participants or Parent(s)/legal guardian(s) willing and able to complete the informed consent process

Exclusion criteria

• Brain calcification caused by specific secondary factors such as infection, poisoning, and trauma
• Participants declining or unable to comply with trial procedures and visit schedule