A Resilience-Based Approach to Improve Long-term Quality of Life in Post-treatment Lymphoma Survivorship

Mass General Brigham

Status: Not yet enrolling

Conditions: Lymphoma

Treatments: Other: Health Education Program; Other: SMART3RP-Lymphoma

Study type: Interventional

Funder types: Other

Identifiers

NCT07013435

25-204

Details and patient eligibility

About

The goal of this trial is to learn if a resilience intervention can lead to improvements in lymphoma survivors' quality of life.

Full description

The Stress Management and Relaxation Response Resiliency Program for lymphoma survivors (SMART3RP-Lymphoma) was adapted by researchers at the MGH. This group program seeks to buffer stress and promote psychological resiliency and physical well-being through a variety of mind-body approaches, such as imagery, relaxation, and yoga, cognitive behavioral strategies, and positive psychology tools.

The main questions it aims to answer are:

• Will survivors randomized to SMART3RP-Lymphoma demonstrate greater improvements in quality of life when compared to survivors randomized to a Health Education Program?
• Will improvements in resiliency lead to improvements in quality of life?

To answer these questions, researchers will compare a resilience intervention tailored to the needs of lymphoma survivors (SMART3RP-Lymphoma) to a Health Education Program to see how they affect quality of life of lymphoma survivors.

Participants will:

• Fill out 4 surveys across 12 months
• Participate in 8 weekly, virtual group sessions
• Submit hair cortisol samples

Enrollment: 254 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• English or Spanish speaking adults (18+ at time of enrollment)
• Within 2 years of completing active, curative treatment for lymphoma (includes surgery, chemotherapy, immunotherapy, radiation therapy, or other)

Exclusion criteria

• Active psychiatric or cognitive comorbidity as determined by the site PI or treating clinician

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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254 participants in 2 patient groups

Health Education Program

Active Comparator group

Description:

Participants will participate in 8 weekly sessions. Components include: * education on the co-occurrence of mental and physical problems * goal setting for health behavior change * self-monitoring HEP is an active control condition for mind body programs and is structurally equivalent to SMART3RP

Treatment:

Other: Health Education Program

SMART3RP-Lymphoma

Experimental group

Description:

Participants will participate in 8 weekly sessions. The intervention components include: * Eliciting the relaxation response (RR), * CBT strategies to improve stress management * Positive psychology strategies to achieve growth enhancement

Treatment:

Other: SMART3RP-Lymphoma