A Retrospective Cohort Analysis of SMARCA4-Deficient Lung Cancer

Shanghai Pulmonary Hospital, Shanghai, China

Status: Completed

Conditions: SMARCA4-Deficient Tumor; NSCLC (Advanced Non-small Cell Lung Cancer)

Study type: Observational

Funder types: Other

Identifiers

NCT07121387

L23(357)

Details and patient eligibility

About

This is a single-center retrospective analysis to explore the clinical characteristics, therapeutic efficacy, and tumor immune microenvironment of SMARCA4-deficient advanced non-small-cell lung cancer (NSCLC).

Enrollment: 221 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed with stage III-IV NSCLC according to the American Joint Committee on Cancer staging criteria (7th edition);
• Lesions are measurable according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1;
• Receiving first-line immunotherapy or chemotherapy as anti-tumor treatment.

Exclusion criteria

• SMARCA4 gene test was not performed;
• Not receive treatment;
• Lost to follow-up after one treatment cycle.

Trial design

221 participants in 2 patient groups

SMARCA4-Deficient group

SMARCA4-Intact group