A Retrospective Cohort Study: Influence of MTHFR C677T and A1298C Polymorphisms on the Survival of Pediatric Patients With Non-Hodgkin's Lymphoma

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Sun Yat-sen University

Status

Completed

Conditions

Pediatric Non-Hodgkin Lymphoma

Study type

Observational

Funder types

Other

Identifiers

NCT04469543
SCCCG-NHL2017

Details and patient eligibility

About

The primary purpose of this retrospective study was to investigate the influence of methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphism on the survival of pediatric patients with Non-Hodgkin lymphoma (NHL) treated with modified NHL-BFM95 protocol in south China.

Enrollment

374 patients

Sex

All

Ages

Under 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • aged ≤ 18 years;
  • newly diagnosed as the four main categories of NHL(Burkitt's lymphoma, lymphoblastic lymphoma, anaplastic large cell lymphoma, and diffuse large B-cell lymphoma) between 2014 and 2020;
  • treated according to the modified BFM95 protocol.

Exclusion criteria

  • aged > 18 years;
  • not newly diagnosed as the four main categories of NHL between 2014 and 2020;
  • treated according to chemotherapeutic regimens except for the modified BFM95 protocol.

Trial design

374 participants in 1 patient group

MTHFR polymorphism

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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