A Retrospective Observational Study on the Effects of Probiotics on HBsAg Clearance

Shandong University

Status: Enrolling

Conditions: Chronic Hepatitis B

Treatments: Drug: PegIFNα2b; Drug: Nucleoside analog; Drug: Nucleoside analog+probiotics; Drug: PegIFNα2b+probiotics

Study type: Observational

Funder types: Other

Identifiers

NCT06313255

KYLL-202301-008-1

Details and patient eligibility

About

The goal of this retrospective observational study is to find out the effects of probiotics on HBV clearance. The main question it aims to answer is:

Are the probiotics have an effect in promoting HBV clearance? The participants will observe the HBV clearance rate in chronic hepatitis B patients receive probiotics in addition to the routine antiviral therapy.

Researchers will compare the HBV clearance rate in chronic hepatitis B patients receive probiotics and antiviral therapy with those receiving solely antiviral therapy.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic hepatitis B patients

Exclusion criteria

• patients with malignancies
• patients with other liver diseases
• pregnancy patients

Trial design

40 participants in 4 patient groups

PegIFNα2b

Treatment:

Drug: PegIFNα2b

PegIFNα2b+probiotics

Treatment:

Drug: PegIFNα2b+probiotics

Nucleoside analog

Treatment:

Drug: Nucleoside analog

Nucleoside analog+probiotics

Treatment:

Drug: Nucleoside analog+probiotics