A Retrospective Study for Nimotuzumab Plus Postoperative Adjuvant Chemotherapy for Resectable Pancreatic Cancer

Shanghai Jiao Tong University logo

Shanghai Jiao Tong University

Status

Completed

Conditions

Resectable Pancreatic Cancer

Treatments

Drug: Nimotuzumab

Study type

Observational

Funder types

Other

Identifiers

NCT06363084
IST-Nim-PC-6

Details and patient eligibility

About

This trial is a retrospective, observational study, patients who underwent surgical resection of the pancreas for non-metastatic pancreatic cancer between 2016 and 2022 were selected and divided into two groups according to with (study arm) or without (control arm) nimotuzumab. The primary efficacy endpoint was overall survival (OS).

Full description

This trial is a retrospective, observational study based on real-world data obtained from the Health Information System (HIS) of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. Patients who underwent surgical resection of the pancreas for non-metastatic pancreatic cancer between 2016 and 2022 were selected and divided into two groups according to with (study arm) or without (control arm) nimotuzumab. The primary efficacy endpoint was overall survival (OS).

Enrollment

64 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age≥18 years old, gender is not limited;
  • Confirmed by histopathological or cytological diagnosis of pancreatic cancer;
  • Underwent surgical resection of the pancreas for non-metastatic pancreatic cancer (including resectable/borderline resectable pancreatic cancer, or locally advanced pancreatic cancer);
  • Received Nimotuzumab plus adjuvant chemotherapy or adjuvant chemotherapy alone after surgery.

Exclusion criteria

  • Patients with other primary malignancies other than pancreatic cancer;
  • Evidence of recurrence or distant metastasis before surgery
  • Received immunotherapy drugs (such as PD-1 inhibitors, etc.) used during adjuvant therapy, or proprietary Chinese medicines with anti-tumor indications, or hyperthermia, targeted therapy drugs other than nimotuzumab;
  • Key information is missing (e.g., primary endpoint data were not available).

Trial design

64 participants in 2 patient groups

study arm
Description:
Nimotuzumab plus adjuvant chemotherapy
Treatment:
Drug: Nimotuzumab
control arm
Description:
adjuvant chemotherapy alone (without Nimotuzumab)

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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