A Retrospective Study in Patients With Liver Injury After the Use of Novel Antineoplastic Agents

Drug Induced Liver Disease Study Group

Status: Active, not recruiting

Conditions: Liver Injury; Liver Injury, Drug-Induced

Study type: Observational

Funder types: Other

Identifiers

NCT06670391

GM_DILI_002

Details and patient eligibility

About

This is an open-enrollment, retrospective, observational study without interventions. Its primary objective is to understand 1) incidence of liver injury among all the hospitalized patient from participating centers after the administration of immune checkpoint inhibitors or molecularly targeted agents; 2) epidemiologic and clinical characteristics of liver injury, including suspected medications, clinical types, histological characteristics, severity, treatment and outcomes.

Enrollment: 2,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Abnormality of liver biochemistry after the administration of any molecularly targeted agent or immune checkpoint inhibitor

Exclusion criteria

• Missing major baseline or clinical data
• Prior liver loco-regional therapy or surgery