A Retrospective Study on the Effect of Male Progressive Sperm Count After Semen Pretreatment on ICSI Fertilization Outcome

Reproductive & Genetic Hospital of CITIC-Xiangya

Status: Completed

Conditions: Sperm Count, Low; Reproductive Sterility

Treatments: Other: semen pretreatment

Study type: Observational

Funder types: Other

Identifiers

NCT03594201

KYXM-201803

Details and patient eligibility

About

The investigators plan to retrospectively analyze clinical data from 14,189 fresh ICSI cycles in Reproductive and Genetic Hospital of CITIC-Xiangya from January 2016 to December 2017.The investigators will regard total progressive sperm number of 2 x 10^6 after pretreatment as the boundary value, and will divide total progressive sperm number of 2 x 10^6 after pretreatment into 2 x 10^6 or higher and < 2 x 10^6 groups, and will further divide < 2 x 10^6 group into: = 0, (0,10^6], (10^6, 2 x 10^6) three groups. Propensity score matching will be used to balance the baseline data between four groups. The matching variables are age, female BMI, AFC, AMH and ICSI.

Enrollment: 12,215 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• infertility female and sterility male for reproductive treatment

Exclusion criteria

• chromosomal abnormalities
• none retrieval oocyte
• none oocyte for ICSI
• Recurrent abortion
• female age≥37 years
• Assisted hatching
• abnormal oocyte zona pellucida
• In Vitro Maturation
• AZF microdeletion

Trial design

12,215 participants in 4 patient groups

group1

Description:

A+B grade sperm count after treatment=0

Treatment:

Other: semen pretreatment

group2

Description:

0\<A+B grade sperm count after treatment≤10\^6

Treatment:

Other: semen pretreatment

group3

Description:

10\^6\<A+B grade sperm count after treatment\<2\*10\^6

Treatment:

Other: semen pretreatment

group4

Description:

A+B grade sperm count after treatment≥2\*10\^6

Treatment:

Other: semen pretreatment