A Role for Brown Adipose Tissue in Postprandial Thermogenesis?

Bayside Health

Status

Terminated

Conditions

Diabetes

Obesity

Cardiovascular Disease

Treatments

Dietary Supplement: Meal

Study type

Interventional

Funder types

Other

Identifiers

NCT01974778

345-13

Details and patient eligibility

About

Brown adipose (fat) tissue (BAT) is a type of fat tissue found in certain small rodents and human babies that is capable of extremely high rates of energy burning. We now know that in adult humans it is present and also able to burn energy.

In addition to increased energy expenditure during cold exposure, energy burning is also increased after consuming a meal. Animal studies have shown that part of this additional energy consumption is contributed by BAT. In the present study we will aim to examine whether BAT activity is increased after a meal.

Full description

The purpose of this project is to measure whether BAT activity (during which BAT increases energy burning) increases in response to ingestion of a meal.

BAT is one of two types of fat, (the other being white fat), which is found in humans and other mammals. In this study we aim to further our understanding of how BAT works in humans. Studies in animals show that in addition to cold exposure, BAT is also activated by ingestion of a meal, and to different amounts depending on the meal composition, and more importantly, total energy content. However we have only a very limited understanding of BAT function in response to meals in humans. Since BAT function is defective in obesity, and its activity and function are impacted by diet, here we will find out whether a single high energy meal composed entirely of lipid (fat) can increase BAT activity. In future these findings and those of subsequent studies may have important implications for the management of obesity and related diseases.

A total of 20 people will participate in this project. Participation will involve a total of 3 visits, including a screening visit, 2 experimental visits consumption of the treatment meal on one visit, and the placebo (dummy) on the other in a randomised order.

Enrollment

4 patients

Sex

Male

Ages

19 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Males aged 19 - 35 years
Unmedicated for the previous 2 months
No major illness
BMI 17-40 kg/m2

Exclusion criteria

Unable to give informed consent
Smokers
Participant in research projects involving ionising radiation within the past 5 years, excluding dual energy x-ray absorptiometry scans conducted in prior studies
Claustrophobia
Fasting plasma glucose > 6.0 mmol/L