A Russian Prospective Observational Study of Invasive Fungal Infections in Patients With Acute Leukemia and Hematopoietic Stem Cell Transplantation

National Hematological Society, Russia

Status: Completed

Conditions: Invasive Fungal Infections

Study type: Observational

Funder types: Other

Identifiers

NCT01519648

RIFI

Details and patient eligibility

About

Estimate the rate of occurrence of Invasive Fungal Infections (IFIs) in patients with acute leukemia for the first 6 months of chemotherapy (that usually correspond to four courses of chemotherapy), and hematopoietic stem cells transplantation.

Full description

This multi-center observational study of IFI in high risk hematological patients, the study will investigate the epidemiology of IFI, describe antifungal strategy, proportion of antifungal prophylaxis, empiric therapy, pre-emptive therapy and targeted therapy in at-risk patients.

Enrollment: 808 patients

Sex: All

Ages: 1 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Diagnosed with de novo or relapsed AL (AML, ALL)started chemotherapy
• All newly allogeneic or autologous transplant recipients during the study period

Trial design

808 participants in 2 patient groups

Acute leukemia patients

Description:

Patients with de novo or relapsed acute myeloid and lymphoid leukemia

Allo- or auto- transplant recipients