A Safety Study of Pentamidine in Patients With Metastatic Colon Cancer Undergoing Standard Chemotherapy as Second-line and/or Third-line Treatment

Oncozyme Pharma

Status and phase

Completed

Phase 2

Phase 1

Conditions

Colorectal Cancer

Treatments

Drug: pentamidine

Study type

Interventional

Funder types

Industry

Identifiers

NCT00809796

OP-103

Details and patient eligibility

About

The purpose of this study is to investigate the safety and possible efficacy of the use of pentamidine in the treatment of colon cancer metastasis in subjects receiving standard therapy.

Enrollment

15 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologically or cytologically proven diagnosis of adenocarcinoma of the colon or rectum with evidence of (1) unresectable, locally recurrent, or (2) metastatic disease
Failure of first-line or second-line therapy for colorectal cancer
At least one unidimensional measurable lesion (on spiral CT scan)
18 years of age or older
ECOG performance status 0, 1 or 2
Serum aspartate transaminase (AST) serum alanine transaminase (ALT) £ 2.5 x upper limit of normal (ULN), or AST and ALT £ 5 x ULN if liver function abnormalities are due to underlying malignancy
Total serum bilirubin £ 1.5 x ULN
Serum albumin ≥ 3.0 g/dL
lipase within normal limits
Absolute neutrophil count (ANC) ≥ 1500/uL (1.5 x 109/L)
Platelets ≥ 100,000/uL
Hemoglobin ≥ 9.0 g/dL
Serum creatinine £ 1.5 x ULN or calculated creatinine clearance ≥ 50 ml/min
Magnesium ≥ lower limit of normal
CEA level ≥ 3.4 ng/ml
Normal ECG
Signed and dated informed consent document indicating that the subject (or legally acceptable representative) has been informed of all the pertinent aspects of the trial prior to enrollment
Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other trial procedures
Life expectancy, in the opinion of the investigator, > 3 months

Exclusion criteria

BP < 100 (systolic)
History of renal disease, pancreatitis, or diabetes mellitus
Peripheral sensory neuropathy (> Grade 1, as per NCI CTCAE version 3.0)
Concomitant therapy with other investigational agents or participation in another clinical trial
Any of the following conditions: Ongoing cardiac dysrhythmias of NCI CTCAE grade ≥ 2; atrial fibrillation of any grade; QTc interval >450 msec for males or >470 msec for females or uncontrolled intercurrent illness, e.g., unstable angina; severe coronary disease, ventricular arrhythmias, bradycardia <50 bpm
Active uncontrolled bacterial infection
Concurrent use of drugs that could prolong QT interval
Concurrent use of nephrotoxic drugs, including aminoglycosides, ampho B, foscarnet, cidofovir
Concurrent use of drugs that may be associated with pancreatitis
Concurrent active cancer originating from a primary site other than colon/rectum, except for surgically treated nonmelanoma skin cancer, in situ cervical cancer, or localized prostate cancer with undetectable PSA level
Co-existing lung disease
History of allergy or hypersensitivity to pentamidine Pregnancy or breastfeeding. All female patients with reproductive potential must have a negative pregnancy test (serum or urine) prior to first dose of study medication.
Severe acute or chronic medical or psychiatric condition, or laboratory abnormality that would impart, in the judgement of the investigator, excess risk associated with trial participation of study drug administration, or which in the judgement of the investigator, would make the subject inappropriate for entry into this trial.
On oral anticoagulants