A Safety Study Using Pentamidine in Patients With Pancreatic Cancer Undergoing Standard Therapy

Oncozyme Pharma

Status and phase

Completed

Phase 2

Phase 1

Conditions

Pancreatic Cancer

Treatments

Drug: Pentamidine

Study type

Interventional

Funder types

Industry

Identifiers

NCT00810953

OP-103-P

Details and patient eligibility

About

The purpose of this study is to investigate the safety and possible efficacy of the use of pentamidine in the treatment of pancreatic cancer metastasis in subjects receiving standard therapy.

Enrollment

10 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologically or cytologically proven diagnosis of advanced pancreatic adenocarcinoma that is unresectable or metastatic. At least one uni-dimensionally measurable lesion (on spiral CT scan)
18 years of age or older
ECOG performance status 0, 1 or 2
Serum aspartate transaminase (AST) serum alanine transaminase (ALT) £ 2.5 x upper limit of normal (ULN), or AST and ALT £ 5 x ULN if liver function abnormalities are due to underlying malignancy
Total serum bilirubin £ 2 x ULN
lipase within normal limits (1.5x ULN)
Absolute neutrophil count (ANC) ≥ 1500/uL (1.5 x 109/L)
Platelets ≥ 100,000/uL
Hemoglobin ≥ 9.0 g/dL
Serum creatinine £ 1.5 x ULN or calculated creatinine clearance ≥ 50 ml/min
CA19-9 level ≥ 37 U/ml
Normal ECG
Signed and dated informed consent document indicating that the subject (or legally acceptable representative) has been informed of all the pertinent aspects of the trial prior to enrolment
Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other trial procedures
Life expectancy, in the opinion of the investigator, > 3 months

Exclusion criteria

BP < 100 (systolic)
History of uncontrolled renal disease, pancreatitis, or diabetes mellitus
Peripheral sensory neuropathy (> Grade 1, as per NCI CTCAE version 3.0)
Concomitant therapy with other investigational agents or participation in another clinical trial within the previous 3 months.
Any of the following conditions: Ongoing cardiac dysrhythmias of NCI CTCAE grade ≥ 2; atrial fibrillation of any grade; QTc interval >450 msec for males or >470 msec for females or uncontrolled intercurrent illness, e.g., unstable angina; severe coronary disease, ventricular arrhythmias, bradycardia <50 bpm
Active uncontrolled bacterial infection
Concurrent use of drugs that could prolong QT interval
Concurrent use of nephrotoxic drugs, including aminoglycosides, ampho B, foscarnet, cidofovir
Concurrent use of drugs that may be associated with pancreatitis
Concurrent active cancer originating from a primary site other than pancreas or history of cancer < 3 years except for skin superficial bladder, uterus etc
History of allergy or hypersensitivity to pentamidine
Pregnancy or breastfeeding. All female patients with reproductive potential must have a negative pregnancy test (serum or urine) prior to first dose of study medication.
Severe acute or chronic medical or psychiatric condition, or laboratory abnormality that would impart, in the judgement of the investigator, excess risk associated with trial participation of study drug administration, or which in the judgement of the investigator, would make the subject inappropriate for entry into this trial.
On oral anticoagulants (LMWH is acceptable)