A SBT-based Protocol-directed Program in Difficult-to-Wean Patients

JinyanXing

Status: Unknown

Conditions: Respiration, Artificial

Treatments: Procedure: a weaning protocol

Study type: Interventional

Funder types: Other

Identifiers

NCT05035355

QYFYWZLL26347

Details and patient eligibility

About

Weaning patients from a ventilator is one of the most challenging processes in an intensive care unit. The investigators aimed to determine whether spontaneous breathing trial (SBT)-based protocol-directed weaning combined with the high-flow nasal cannula (HFNC) could be superior to routine SBT-based weaning in reducing the duration of mechanical ventilation (MV) in difficult-to-wean patients.

Enrollment: 200 estimated patients

Sex: All

Ages: 16 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥ 16 years old
• MV for more than 48 hours
• intubated or tracheostomized

Exclusion criteria

• pregnancy
• irreversible respiratory failure caused by neurodegenerative disorders, such as Alzheimer disease, motor neuron disease, or multiple system atrophy
• pre-existing decision to limit life support
• waiving of MV during treatment
• terminal stage of severe illness

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

200 participants in 2 patient groups

weaning protocol group

Experimental group

Description:

spontaneous breathing trial (SBT)-based protocol-directed weaning combined with the high-flow nasal cannula group

Treatment:

Procedure: a weaning protocol

routine SBT weaning group

No Intervention group