A Single Case Study of Hypermetabolism

The Hospital for Sick Children

Status: Completed

Conditions: Luft Disease; Hypermetabolism Due to Defect in Mitochondria

Treatments: Diagnostic Test: 18F FDG PET/CT

Study type: Interventional

Funder types: Other

Identifiers

NCT04805268

1000061502

Details and patient eligibility

About

In the Metabolic Disorder clinic at The Hospital for Sick Children, the investigators identified a male, proband with possible Luft's disease. The investigators hypothesize that Luft's disease is caused by excess or dysregulation of brown/beige fat tissue.

To address the hypothesis, the investigators would like to assess brown fat distribution and activity in this subject.

Full description

The subject will undergo a fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F FDG PET/CT) at the Diagnostic Imaging unit of The Hospital for Sick Children.

Enrollment: 1 patient

Sex: All

Ages: 9 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of hypermetabolism, possible Luft's disease.

Exclusion criteria

• None

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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1 participants in 1 patient group

One subject with possible Luft's disease

Experimental group

Description:

18F-FDG will be administered I.V., approximately 1 hour prior to PET/CT scan.

Treatment:

Diagnostic Test: 18F FDG PET/CT