A Single-center Pilot Study Evaluating the Immediate Effects of Low-dose Acetazolamide on Respiratory Control in Subjects With Treatment Emergent Sleep Disordered Breathing

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NYU Langone Health

Status

Withdrawn

Conditions

Sleep Apnea

Treatments

Drug: Acetazolamide

Study type

Interventional

Funder types

Other

Identifiers

NCT02670096
15-00756

Details and patient eligibility

About

This is a single center pilot study evaluating the immediate effects of low-dose acetazolamide on respiratory control in subjects with treatment emergent sleep disordered breathing. The purpose of this study is to assess the immediate effect one-time low-dose acetazolamide on sleep breathing in (Treatment Emergent Sleep Disordered Breathing) TE-CSA subjects compared to subjects' baseline evaluation without acetazolamide. Investigators will also try to determine the immediate effect of one-time low-dose acetazolamide on subjects' resting ventilation and ventilatory response slope compared to subjects' baseline evaluation without acetazolamide.

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age ≥18 to 80 years
  • TE-CSA
  • Subjects are capable of giving informed consent

Exclusion criteria

  • Hypersensitivity to acetazolamide or other sulfonamides
  • Intake of carbonic anhydrase inhibitors within the last 72 hours
  • Intake of medication that influences breathing, sleep, arousal or muscle physiology
  • Cheyne-Stokes respiration
  • Heart failure
  • Renal failure
  • Liver failure
  • Chronic hypercapnea
  • Hyponatremia
  • Hypokalemia
  • Pregnancy
  • Breastfeeding mothers
  • Active drug/alcohol dependence or abuse history

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

0 participants in 1 patient group

Reference therapy
Experimental group
Description:
Baseline evaluation of subjects without acetazolamide administration Follow up evaluation of subjects one hour after acetazolamide administration
Treatment:
Drug: Acetazolamide

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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