A Single-center Pilot Study Evaluating the Immediate Effects of Low-dose Acetazolamide on Respiratory Control in Subjects With Treatment Emergent Sleep Disordered Breathing
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This is a single center pilot study evaluating the immediate effects of low-dose acetazolamide on respiratory control in subjects with treatment emergent sleep disordered breathing. The purpose of this study is to assess the immediate effect one-time low-dose acetazolamide on sleep breathing in (Treatment Emergent Sleep Disordered Breathing) TE-CSA subjects compared to subjects' baseline evaluation without acetazolamide. Investigators will also try to determine the immediate effect of one-time low-dose acetazolamide on subjects' resting ventilation and ventilatory response slope compared to subjects' baseline evaluation without acetazolamide.
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Inclusion criteria
- Age ≥18 to 80 years
- TE-CSA
- Subjects are capable of giving informed consent
Exclusion criteria
- Hypersensitivity to acetazolamide or other sulfonamides
- Intake of carbonic anhydrase inhibitors within the last 72 hours
- Intake of medication that influences breathing, sleep, arousal or muscle physiology
- Cheyne-Stokes respiration
- Heart failure
- Renal failure
- Liver failure
- Chronic hypercapnea
- Hyponatremia
- Hypokalemia
- Pregnancy
- Breastfeeding mothers
- Active drug/alcohol dependence or abuse history
Trial design
Primary purpose
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Interventional model
Masking
0 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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