A Single Intraarticular Injection of Platelet-Rich Plasma on Pain and Physical Function in Patients With Ankle OA

Kaohsiung Veterans General Hospital

Status

Completed

Conditions

Ankle Osteoarthritis

Treatments

Other: PRP

Study type

Interventional

Funder types

Other

Identifiers

NCT04022928

VGHKS18-CT7-21

Details and patient eligibility

About

Platelet-rich plasma (PRP) has been reported to be an effective treatment for knee osteoarthritis (OA). The application in ankle OA has rarely been investigated. The aim was to evaluate the efficacy and safety of a single intraarticular injection of PRP for the treatment of patients with ankle OA.

Full description

Methods: In a prospective study, patients with symptomatic ankle OA for at least 6 months were recruited. Patients received a single injection of 3-ml of PRP into symptomatic ankles. The primary outcome was the change from baseline in the visual analog scale (VAS) pain score (0-10cm) at 6 months. Secondary outcomes included the Ankle Osteoarthritis Scale (AOS) score, American Orthopedic Foot and Ankle Society (AOFAS) ankle/hindfoot score, single leg stance test (SLS), use of rescue analgesics and patient satisfaction. Adverse events were recorded during the study.

Patients were followed at 1, 3 and 6 months postinjection .

Enrollment

44 patients

Sex

All

Ages

20 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age of at least twenty years
Ankle pain lasted for at least 6 months, despite conservative treatment or inability to tolerate the side effects of medications
Ankle radiographs taken within 6 months (reviewed by the senior author) were equivalent to grade 1-4 osteoarthritis by the Kellgren Lawrence grading system
Average ankle pain of > 3cm on a 10-cm visual analog scale (VAS)
Radiological evidence of bilateral ankle osteoarthritis was accepted if VAS pain in the contralateral ankle was < 3 cm
Normal activity level, not bedridden or confined to a wheelchair, able to walk 30 meters without the aid of a walker, crutches or cane
No use of physical therapy or changes in shoes or orthotic devices during the study

Exclusion criteria

Pregnancy or lactation in women
Lower leg trauma in a location other than within the ankle
Previous surgery involving the spine, hip or knee
The presence of an active infection of the ankle
Surgery involving the affected ankle within the previous 12 months
Intraarticular steroid or hyaluronate injection in the ankle within the previous 6 months
Treatment with anticoagulants or immunosuppressives
History of rheumatoid arthritis, gout, or other inflammatory arthropathy
The presence of visual or vestibular impairments
Poor health status (such as a neoplasm, diabetes mellitus, or paresis) that would interfere with the assessments