a Single Intraarticular Injection of PRP for Early Knee OA

Kaohsiung Veterans General Hospital

Status

Completed

Conditions

Knee Osteoarthritis

Treatments

Other: PRP

Study type

Interventional

Funder types

Other

Identifiers

NCT04027738

VGHKS106-131

Details and patient eligibility

About

This study aimed to investigate the efficacy of a single intraarticular injection of PRP for the treatment of early knee OA.

Full description

Platelet-rich plasma (PRP) has been reported to be effective for the treatment of knee osteoarthritis (OA). This study aimed to investigate the efficacy of a single intraarticular injection of PRP for the treatment of early knee OA.

In a prospective trial with 6-month follow-up, patients with early knee OA were recruited and received a single intraarticular PRP injection. Several outcomes were measured.

Enrollment

41 patients

Sex

All

Ages

20 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

aged 20-70 years
symptomatic knee OA with pain for at least 6 months despite conservative treatment such as analgesics, NSAIDs and/or physical therapy
average knee pain of at least 30 mm on a 100-mm visual analog (VAS) scale
grade 1 or 2 knee OA according to the Kellgren-Lawrence grading system based on -radiographs taken within the previous 6 months
Radiological evidence of bilateral knee OA was accepted if global pain VAS in the contralateral knee was less than 30 mm.

Exclusion criteria

previous orthopedic surgery on the spine or lower limbs
disabling OA of either hip or foot
knee instability or marked valgus/varus deformity
history of severe knee trauma; intraarticular injections into the knee in the past 6 months
infections or skin diseases around the target knee
women ascertained or suspected pregnancy or lactating
presence of malignancy, hematological disease, collagen vascular diseases, or autoimmune diseases;
therapy with anticoagulants or anti-aggregating agent
serious medical conditions that would interfere with the assessments during the study.