A Study Comparing Radiofrequency Ablation and Hepatic Resection for Hepatocellular Carcinoma

Seoul National University

Status: Terminated

Conditions: Carcinoma, Hepatocellular

Treatments: Procedure: Radiofrequency ablation; Procedure: Hepatic resection

Study type: Interventional

Funder types: Other

Identifiers

NCT02482909

0520090

Details and patient eligibility

About

The purpose of this prospective randomized study is to compare the efficacy and safety of radiofrequency ablation and hepatic resection for small hepatocellular carcinomas with very homogeneous underlying conditions.

Enrollment: 68 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age between 20 and 70 years
2. Child-Pugh class A (score 5-6)
3. Single hepatocellular carcinoma
4. Maximal diameter of the tumor from 2 to 4 cm when measured on MRI or CT (The diameter on MRI was measured prior to that on CT)
5. No previous treatment
6. Platelet count > 80,000/mm3

Exclusion criteria

1. HCC abutting main hepatic veins or the first branches of the main portal vein
2. HCC abutting vessels ≥ 0.5 cm

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

68 participants in 2 patient groups

Hepatic resection

Experimental group

Description:

Hepatic resection is performed as a primary treatment for hepatocellular carcinoma.

Treatment:

Procedure: Hepatic resection

Radiofrequency ablation

Experimental group

Description:

Radiofrequency ablation is performed as a primary treatment for hepatocellular carcinoma.

Treatment:

Procedure: Radiofrequency ablation