A Study Comparing the Efficacy of Two Topical Steroid Application Regimens in Pediatric Patients With Atopic Dermatitis

Yale University

Status: Completed

Conditions: Atopic Dermatitis

Treatments: Other: Soak and smear; Other: Dry Smear

Study type: Interventional

Funder types: Other

Identifiers

NCT01675232

HIC-1206010366

Details and patient eligibility

About

The purpose of this study is to investigate the efficacy of two different corticosteroid ointment application regimens for the treatment of eczema (atopic dermatitis).

Enrollment: 45 patients

Sex: All

Ages: 2 weeks to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Meet the clinical criteria for the diagnosis of atopic dermatitis
• Have disease over at least 5% of their total body surface area.
• Less than 18 years of age.
• Families able to comprehend written instructions in English and able to complete questionnaires with assistance if needed.
• Parents/guardians able to understand and willing to sign a parental permission form.
• Children between the ages of 7-17 years willing to sign an age-appropriate assent form.

Exclusion criteria

• Patients who are allergic or intolerant of the topical medications employed in this study.
• Lack of follow-up after initial visit or regimen noncompliance.
• Patients who do not have access to a bathtub.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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45 participants in 2 patient groups

Soak and smear

Active Comparator group

Description:

Application of hydrocortisone 2.5% ointment or triamcinolone acetonide 0.1% ointment immediately to wet skin once a day and dry skin once a day.

Treatment:

Other: Soak and smear

Dry smear

Active Comparator group

Description:

Application of hydrocortisone 2.5% ointment or triamcinolone acetonide 0.1% ointment to dry skin twice a day.

Treatment:

Other: Dry Smear