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About
The purpose of this study is to evaluate the safety, tolerability, and preliminary efficacy of a second course of TPX-100 administered by intra-articular injection to subjects with osteoarthritis of the knee who participated in study TPX-100-1.
Full description
Recruit up to 70 subjects whom participated in protocol TPX-100-1. The opposing knee that was treated will be getting 200mg in 4 weekly injections. The knee that was treated in TPX-100-1 will get randomized to either 200mg dose or a placebo lookalike. The investigators will follow these subjects for 6 months. Two MRIs of bi-lateral knees will be assessed. Also collection of ADA samples at 4 time points through the 6 month period.
Enrollment
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Volunteers
Inclusion criteria
Previous enrollment in study TPX-100-1
Able to read, understand, sign and date the subject informed consent
Willingness to use only acetaminophen as the primary analgesic (pain-relieving) study medication during the injection period and through study day 30. The maximum dose of acetaminophen must not exceed 2 grams/day (2000 mg per day).
Willingness to use only hydrocodone or hydrocodone/acetaminophen (e.g. Norco) for breakthrough pain through study day 30.
Willingness not to use non-steroidal anti-inflammatory drugs (NSAIDS) such as aspirin, ibuprofen, naproxen through study day 30.
Female subjects of child bearing potential who are sexually active (non-abstinent) must agree to and comply with using 2 highly effective methods of birth control (oral contraceptive, implant, injectable or indwelling intrauterine device, condom with spermicide, or sexual abstinence) while participating in the study.
Exclusion criteria
"Possibly, probably or definitely" drug-related SAEs in TPX-100-1; severe or ongoing "possibly, probably or definitely" related AEs in TPX-100-1.
Contraindication to MRI, including: metallic fragments, clips or devices in the brain, eye, or spinal canal; implanted devices that are magnetically programmed; weight > 300 lbs.; moderate or severe claustrophobia; previous intolerance of MRI procedure
Prior surgery in the knees, excluding procedures for debridement only (no previous microfracture procedure)
Joint replacement or any other knee surgery planned in the next 12 months
History of rheumatoid arthritis, psoriatic arthritis, or any other autoimmune or infectious cause for arthritis
Knee effusion > 2+ on the following clinical scale:
Last viscosupplementation (e.g. Synvisc® or similar hyaluronic acid product) injected into either knee < 3 months before screening
Last intra-articular knee injection of corticosteroids < 2 months before screening
Use of any steroids (except inhaled corticosteroids for respiratory problems) during the previous month before screening
Known hypersensitivity to TPX-100
Known hypersensitivity to acetaminophen or hydrocodone
History of arthroscopy in either knee in the last 3 months before screening
History of septic arthritis, gout or pseudo-gout, of either knee in previous year before screening
Clinical signs of acute meniscal tear (locking, new acute mechanical symptoms consistent with meniscal tear)
Patellar chondrocalcinosis on X-Ray
Skin problem, rash or hypersensitivity, affecting either knee at the injection site
Bleeding problem, platelet or coagulation deficiency contraindicating, in the doctor's opinion, intra-articular injection
Active systemic infection
Current treatment or treatment within the previous 2 years prior to the Screening Visit for any malignancy except basal cell or squamous cell carcinoma of the skin, unless with specific written permission is provided by the Sponsor's medical monitor
Women of childbearing potential who are pregnant, nursing, or planning to become pregnant, and those who do not agree to remain on an acceptable method of birth control throughout the entire study period
Participation in other clinical osteoarthritis drug studies, with the exception of TPX-100-1, within one year prior to screening
Currently taking Paclitaxel (mitotic inhibitor), natalizumab (anti-integrin monoclonal antibody), or any other anti-integrin treatment.
History of significant liver disease or consumption of more than 3 alcoholic drinks a day. (Definition of one alcoholic drink: 12-ounces of beer, 8-ounces of malt liquor, 5-ounces of wine, 1.5-ounces or a "shot" of 80-proof distilled spirits or liquor such as gin, rum, vodka, or whiskey).
Primary purpose
Allocation
Interventional model
Masking
14 participants in 3 patient groups, including a placebo group
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Data sourced from clinicaltrials.gov
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