A Study Examining Adolescents With Non-Suicidal Self-Injury (RDoC)

University of Minnesota (UMN)

Status: Active, not recruiting

Conditions: Self-Injurious Behavior; Deliberate Self-Harm

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT02947308

PSYCH-2016-24795

1R01MH107394-01A1 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This study will examine longitudinal brain development in young adolescent girls with a history of Non-Suicidal Self-Injury (NSSI). Specifically, three constructs outlined by the the Research Domains Criteria (RDoC) will be examined through self-assessment, MRI, and a cognitive battery.

Full description

This study is designed to study brain development in 12-14 year old females with a history of NSSI. Assessments will take place over the course of three years, with three visits per year - a total of nine visits.

The first visit will take place at the Ambulatory Research Center (ARC) at the Fairview Riverside hospital complex. This visit will include a number of questionnaires designed to gather information about the participant's physical and psychological health. Additionally, measures of intelligence quotient (IQ) and demographics will be assessed.

The second visit will again take place at the ARC. For this visit, participants will be asked to partake in the Trier Social Stress Test (TSST) in which they prepare a short, five-minute speech and deliver the speech to an audience with an additional task to follow. The TSST will be videotaped. Following the completion of this task, the participant will complete computer tests in order to measure things like attention and memory. During the second visit, five saliva samples will be collected to measure levels of the hormone Cortisol. The participant will need to collect additional saliva samples at home.

The third visit will take place at the University of Minnesota Center for Magnetic Resonance Research (CMRR) and will involve a brain MRI. Before the MRI the participant will be asked to provide a urine sample and complete a drug and pregnancy test. During the MRI, the participant will be asked to lie quietly in the scanner. The participant will do activities such as resting, listening to music, and playing games using a button box while in the scanner.

The participant will need to come in to complete these assessments twice more at one and two years following the completion of the first set of visits - a total of nine visits overall.

Enrollment: 168 patients

Sex: Female

Ages: 12 to 16 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 12-16 years old
• Female
• Has had first menstruation
• Willingness to have de-identified data shared with RDoC database

Inclusion Criteria - Adolescents with Non-Suicidal Self-Injury:

• Any history of self harm

Inclusion Criteria - Healthy Controls:

• No history of self harm

Exclusion criteria

• Male
• Pregnancy
• MRI Incompatibility
• IQ of less than 80
• Major Medical Illness
• Diagnosis of any of the following: Primary Psychotic Disorder, Bipolar Spectrum Disorder, Autism Spectrum Disorder, Current or Past Substance Use Disorder

Trial design

168 participants in 2 patient groups

Adolescents with NSSI

Description:

12-16 year old females who have a history of non-suicidal self-injury are included in this cohort. No interventions will be administered.

Healthy Controls

Description:

12-16 year old females with no history of non-suicidal self-injury are included in this cohort.