A Study for Absorption of Intranasal Epinephrine Compared to Conventional Intramuscular Epinephrine

Siriraj Hospital

Status: Completed

Conditions: Anaphylaxis

Treatments: Drug: Epinephrine

Study type: Interventional

Funder types: Other

Identifiers

NCT01432522

078/2550

Details and patient eligibility

About

This study is a preliminary report of pharmacokinetic data of epinephrine administered via intranasal route (IN) comparing with intramuscular (IM) route in healthy adult volunteers.

Full description

Patients are reluctant to use Epipen® on emergency basis, perhaps because of improperly training, hesitancy and fear of needle. Other route of administration of epinephrine (EPI) may be more benefit such as intranasal route.

Enrollment: 12 estimated patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Healthy subjects
2. 18-30 years-old

Exclusion criteria

1. Pregnancy
2. Subjected who use current medication that interfere with result of plasma epinephrine level such as pseudoephedrine

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

---

12 participants in 1 patient group

epinephrine IN, epinephrine IM, saline IN

Experimental group

Description:

1. Intranasal saline 2. Intramuscular epinephrine 3. Intranasal epinephrine

Treatment:

Drug: Epinephrine