A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects

St. Jude Children's Research Hospital

Status and phase

Completed

Phase 2

Conditions

Central Nervous System Tumors

Brain Tumors

Treatments

Procedure: Radiation Therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT00187226

RT1

Details and patient eligibility

About

The purpose of the study was to determine if treating a limited volume of normal tissue surrounding the tumor or tumor bed using conformal radiation therapy would achieve similar rates of disease control compared to standard radiation therapy. The study was also conducted to examine the effect of irradiation on neurological, endocrine and cognitive function.

Full description

Radiation therapy is commonly used to treat a variety of brain tumors in children including ependymoma, craniopharyngioma and low- and high-grade glioma. The ability of the therapy to control brain tumors in children is known to depend on the tumor type, extent of resection and other clinical factors. Children who received radiation therapy on this study were evaluated for treatment failure at 12 months. In addition to the primary objective, the study was designed to explore the association between radiation dose and volume and a variety of neurological, endocrine and cognitive deficits up to 5 years after treatment.

Enrollment

361 patients

Sex

All

Ages

8 months to 25 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Age at time of irradiation is greater than or equal to 8 months and less than or equal to 25 years
Histologically diagnosed craniopharyngioma, ependymoma, low-grade astrocytoma or high-grade glioma and radiographically diagnosed selected patients with craniopharyngioma and low-grade glioma.
Adequate performance status, participant has an ECOG (Performance Status Score) of 0-2(0=Normal Activity; 1=Symptoms but Ambulatory; 2=Bedridden <50% of time)
Histologic type that requires only focal irradiation.
No prior fractionated external beam irradiation
Informed consent signed by patient, parent, or guardian.