A Study of 18F-AlF-NOTA-Neurotensin PET/CT for Imaging Prostate Cancer

Central South University

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Prostate Cancer

Treatments: Drug: 18F-AlF-NOTA-neurotensin

Study type: Interventional

Funder types: Other

Identifiers

NCT03516045

201801002

Details and patient eligibility

About

The aim of this study is to investigate the clinical value of [18F]aluminum fluoride-1,4,7-triazacyclononane-1,4,7-triacetic acid-neurotensin（18F-AlF-NOTA-neurotensin）positron emission tomography / computed tomography (PET/CT) in patients with prostate cancer (PCa).

Full description

18F-AlF-NOTA-neurotensin is a radioligand targeting the neurotensinreceptor, which is widely expressed on the cell surface of PCa. The radioligand can be used for the diagnosis and stage of the PCa. A total of 5 volunteers and 60 PCa patients will be subjected to a 18F-AlF-NOTA-neurotensin PET/CT scan. The uptake of 18F-AlF-NOTA-neurotensin in organs and tumor lesions will be quantified as Standardized Uptake Values (SUVmax/SUVmean).

Enrollment: 65 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Histologically and/or clinically confirmed and/or suspicious of PCa.
2. Signed informed consent.

Exclusion criteria

Claustrophobia (unable to accept PET/CT scanning)

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

65 participants in 1 patient group

18F-AlF-NOTA-neurotensin PET/CT

Experimental group

Description:

One injection of the radioligand 18F-AlF-NOTA-neurotensin Device: PET/CT Following injection of 18F-AlF-NOTA-neurotensin the participants will be subjected to whole body PET/CT

Treatment:

Drug: 18F-AlF-NOTA-neurotensin