A Study of Aerobic Exercise for Patients With Bipolar Disorder

Guangzhou Psychiatric Hospital

Status: Unknown

Conditions: Cognitive Symptom; Bipolar Disorder

Treatments: Behavioral: aerobic exercise; Behavioral: Placebo controlled group

Study type: Interventional

Funder types: Other

Identifiers

NCT03353337

GZ Psychiatric Hospital

Details and patient eligibility

About

This study will investigate the effects of aerobic exercise on mental states, cognition, BDNF, and long-term outcomes in patients with bipolar disorder.

Full description

Multiple cognitive impairments are common in patients with bipolar disorder. Preliminary evidence shows that aerobic exercise might have positive effects in enhancing cognition and improving clinical symptoms in patients with mood disorders. This randomized controlled trial will investigate short-term (1 months) effects of aerobic exercise on cognition and clinical symptoms as well as the long-term (12 months) effects on decreasing the recurrence rate.

Enrollment: 210 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• DSM-IV defined bipolar disorder.
• Never accept aerobic exercise therapy.
• dextromanuality.

Exclusion criteria

• Diagnosed neurological or musculoskeletal disorder/injury,
• Uncontrolled cardiovascular or metabolic diseases that are not suitable for running
• Diagnosed hypertension
• Other diagnosed serious medical conditions that are not suitable for cycling
• Severe suicidal ideation
• Mental retardation
• Currently participating in a exercise program or activity, defined as 30 minutes of vigorous physical activity 4-5 times per week

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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210 participants in 2 patient groups, including a placebo group

aerobic exercise

Experimental group

Description:

Cycling at the intensity of 50%-70% of maximum heart rate (220-age) for 30 mins per day, 4 days per week, last for 1 month.

Treatment:

Behavioral: aerobic exercise

Placebo controlled group

Placebo Comparator group

Description:

General intensity activities of recreation therapy, including Handicraft manufacture, reading activity, singing entertainment, walking.

Treatment:

Behavioral: Placebo controlled group