A Study of ALRT 1057 Topical Gel in Patients With AIDS-Related Kaposi's Sarcoma

Anderson Clinical Research

Status: Completed

Conditions: Sarcoma, Kaposi; HIV Infections

Treatments: Drug: Alitretinoin

Study type: Interventional

Funder types: Industry

Identifiers

NCT00002439

272A

96ACR-LIG1

L1057T-31

Details and patient eligibility

About

The purpose of this study is to see if ALRT1057 gel is safe and effective in treating Kaposi's sarcoma (KS) when applied to skin .

Full description

This is a Phase 3 double-blind study. KS patients are randomized to 1 of 2 treatment arms. They receive either ALRT1057 gel or placebo for 12 weeks. If progressive disease for KS is noted before Week 12, patients are switched to the other blinded treatment arm. If a response or disease progression that has not persisted for at least 4 weeks as of Week 12 occurs, treatment on the blinded arm is continued for up to 4 additional weeks, or until response of disease progression is confirmed. After that time or after 12 weeks of treatment, open-label ALRT1057 may be received.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Information not available