A Study of Bevacizumab and Extended Treatment of Temozolomide in Patients With Recurrent Glioblastoma Multiforme

Roche

Status and phase

Completed

Phase 2

Conditions

Glioblastoma Multiforme

Treatments

Drug: temozolomide

Drug: bevacizumab [Avastin]

Study type

Interventional

Funder types

Industry

Identifiers

NCT01115491

2010-019051-21

ML25152

Details and patient eligibility

About

This is a Phase II, national, multicenter, open-label, non-comparative study to investigate the efficacy and safety of bevacizumab and temozolomide in patients with recurrent glioblastoma multiforme (GBM) after a first treatment failure. Patients will receive bevacizumab 10 mg/kg intravenously every two weeks until disease progression, consent withdrawal, or unacceptable toxicity. Anticipated time on study treatment is 12-24 months.

Enrollment

32 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age >= 18 years
Histological diagnosis of glioblastoma multiforme (GBM) documented by surgical resection or biopsy.
They should be patients in a first relapse treated with radiotherapy and chemotherapy and chemotherapy based on temozolomide 150-200 mg/m2 on days 1 to 5 every 28 days (Stupp regimen) for at least three cycles. At least 4 weeks must have lapsed since previous chemotherapy and 3 months since the last dose of radiotherapy.
Use of an effective contraceptive method by patients and their partners.
Stable or decreasing corticosteroid dose for the five days prior to study entry
Adequate hematological function
Adequate liver function
Adequate kidney function

Exclusion criteria

Signs of recent bleeding at the MRI of the brain. However, patients with clinically asymptomatic presence of hemosiderin, resolving bleeding changes related to surgery, and presence of punctate hemorrhage in the tumor will be allowed to participate in the study.
Prior treatment with bevacizumab
Poorly controlled arterial hypertension
History of hypertensive crises or hypertensive encephalopathy
New York Health Association (NYHA) Class II or higher congestive heart failure
History of myocardial infarction or unstable angina pectoris within six months of study entry
History of stroke or TIA within six months of study entry
Significant vascular disease within six months of study entry
History of hemoptysis > grade 2 according to the NCI CTC criteria within one month of study entry
Evidence of bleeding diathesis or coagulopathy (in the absence of therapeutic anticoagulation)
Major surgery, open biopsy, intracranial biopsy, ventriculoperitoneal shunt, or major traumatic lesion within 28 days of study entry.
Core needle biopsy (excluding intracranial biopsy) or other minor surgery within seven days of randomization. Placement of a central vascular access device (CVAD) if performed in the two days prior to bevacizumab administration
History of abdominal fistula or gastrointestinal perforation within six months of study entry
History of intracranial abscess within six months of randomization
Any prior malignant neoplasm treated with curative intent in the five years prior to study entry, except for adequately controlled limited basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ of the cervix
Patients with any other metabolic or psychological disease
Hypersensitivity to products derived from Chinese hamster ovary cells or to other humanized or recombinant human antibodies