A Study of Breath Testing for Small Intestinal Bacterial Overgrowth

Mayo Clinic

Status: Enrolling

Conditions: Heartburn; Gastroesophageal Reflux; Regurgitation

Treatments: Other: Breath Testing

Study type: Interventional

Funder types: Other

Identifiers

NCT05976165

22-007268

Details and patient eligibility

About

Researchers hope to determine how often small intestinal bacterial overgrowth occurs after taking proton pump inhibitors.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Predominant symptoms of gastroesophageal reflux disease including heartburn, regurgitation
• Subjects must be able to give appropriate informed consent

Exclusion criteria

• Prior diagnosis of SIBO
• Use of PPIs or H2R-anatagonstists in the prior 3 months
• Major concomitant illness (renal, hepatic, rheumatologic or cardiovascular disease, or malignancy)
• Antibiotic therapy within one month
• Prior gastrointestinal surgery including esophageal, gastric, and small or large bowel surgery
• Previously diagnosed irritable bowel syndrome or inflammatory bowel disease
• Individuals who are pregnant or breast feeding
• Patients with plans to become pregnant
• Inability to take PPIs, including allergy/sensitivity

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

Breath Test Evaluation for SIBO

Experimental group

Description:

Subjects with symptoms of gastroesophageal reflux disease (GERD) treated with a short course of proton pump inhibitors (PPI) clinically will undergo breath testing evaluating for small intestinal bacterial overgrowth (SIBO).

Treatment:

Other: Breath Testing