A Study of Carbon-14-Labelled [14C] LY3372689 in Healthy Male Participants

Lilly

Status and phase

Completed

Phase 1

Conditions

Healthy

Treatments

Drug: [¹⁴C]-LY3372689

Study type

Interventional

Funder types

Industry

Identifiers

NCT05749848

18430

I9X-MC-MTAF (Other Identifier)

Details and patient eligibility

About

The main purpose of this study is to evaluate how much of the study drug (LY3372689), administered as a single dose that has the radioactive substance 14C incorporated into it, passes from blood into urine, feces and expired air in healthy male participants. The study will also measure how much of the study drug gets into the bloodstream, how its broken down, and how long it takes the body to get rid of it. The study will last about 4 weeks. Screening is required within 28 days prior to the start of the study and follow up is required approximately 7 days after discharge.

Enrollment

8 patients

Sex

Male

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Male participants who are overtly healthy as determined by medical evaluation
Have a body mass index within the range 18.5 to 32.0 kilograms per meter squared (kg/m²)
Males who agree to use highly effective/effective methods of contraception for 14 weeks following the dose of LY3372689 may participate in this trial.

Exclusion criteria

Have a clinically significant abnormal blood pressure and/or pulse rate as determined by the investigator at screening or check-in
Have significant history of or current cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs
Have evidence of significant active neuropsychiatric disease, as determined by the investigator
Have participated in >3 radiolabeled drug studies in the last 12 months