A Study of Contralateral Limb Block

Mayo Clinic

Status and phase

Enrolling

Phase 4

Conditions

Limb Pain, Phantom

Treatments

Drug: Placebo

Drug: Lidocaine

Study type

Interventional

Funder types

Other

Identifiers

NCT06045936

22-010792

Details and patient eligibility

About

This research is being done to determine if an anesthetic like Lidocaine, may be effective when injected around the sciatic nerve of the intact limb in patients with limb loss pain on the contralateral side.

Enrollment

20 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Lower extremity amputation performed more than 12 months before study enrollment
PLP/RLP in affected amputated limb > 4 on NRS26
Pain duration of more than 6 months despite a trial of conservative therapies for at least 2 months, including oral medications, topical medicines, physical therapy, and physical modalities (i.e., heat, cold, transcutaneous electrical nerve stimulation, phonophoresis)
Willingness to undergo image guided diagnostic nerve block

Exclusion criteria

Refusal / inability to participate or provide consent
Contraindications to diagnostic nerve block
Non-neurogenic source of PLP/RLP
Current opioid use > 50 morphine milligram equivalents per day
Any interventional pain treatment in the residual limb within the last 30 days
Severe uncontrolled medical condition (i.e., hypertensive crisis, decompensated hypothyroidism)
Use of investigational pain drug within past 30 days or other concurrent clinical trial enrollment