A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi

Mayo Clinic

Status and phase: Enrolling; Phase 4

Conditions: Ureteroscopy; Post Operative Pain

Treatments: Drug: Corticosteroid; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT07223580

25-003416

Details and patient eligibility

About

The purpose of this research is to evaluate if corticosteroid (prednisone) after ureteroscopy and placement of the stent will help alleviate postoperative pain control in addition to other normal postoperative pain medications

Enrollment: 90 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who are diagnosed with kidney or ureteral stones confirmed on imaging (CT of the abdomen or pelvis) and who elect for definitive treatment via ureteroscopy with placement of ureteral stent.
• Age 18 years or older
• Patients of either gender
• Patients of all ethnic backgrounds
• Cable of giving informed consent
• Capable and willing to fulfill the requirements of the study.

Exclusion criteria

• History of chronic pain
• Chronic use of opioids or other pain medication (>12 weeks)
• Known allergies to corticosteroids.
• Known or suspected pregnancy
• Inability to give informed consent or unable to meet requirements of the study for any reason.
• Bilateral ureteroscopy
• Current Corticosteroid Use
• Diabetic patients who are insulin dependent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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90 participants in 2 patient groups, including a placebo group

Standard of care plus Corticosteroid

Experimental group

Description:

Participants will receive standard of care postoperative ureteroscopy medication, with the addition of prednisone 25 mg.

Treatment:

Drug: Corticosteroid

Standard of Care

Placebo Comparator group

Description:

Participants will receive standard of care postoperative ureteroscopy medication, with the addition of a placebo pill.

Treatment:

Other: Placebo