A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis

Mayo Clinic

Status: Completed

Conditions: Eosinophilic Esophagitis

Treatments: Diagnostic Test: Esophageal String Test (EST); Diagnostic Test: High Resolution Esophageal Manometry (HREM); Other: Colgate

Study type: Interventional

Funder types: Other

Identifiers

NCT05482256

22-003963

Details and patient eligibility

About

The purpose of this research is to determine if detergents in everyday products such as toothpaste make the lining of the esophagus leaky and cause allergic inflammation.

Enrollment: 12 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Normal, healthy volunteers.
• Able to swallow pills.

Exclusion criteria

• Personal history of esophageal disease including but not limited to eosinophilic esophagitis, esophageal dysmotility, or GERD/reflux.
• History of dysphagia (i.e., difficulty swallowing), chronic vomiting, chronic abdominal pain, unintentional weight loss.
• Celiac disease, inflammatory bowel disease, irritable bowel syndrome, esophageal varices, chronic aspiration, connective tissue disorder, or known parasitic infection.
• Gelatin allergy.
• Use of a toothpaste containing SLS within 2 weeks of the study.
• Pregnancy.

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

Toothpaste detergents with Eosinophilic Esophagitis Testing

Experimental group

Description:

Subjects will complete an esophageal string test prior to and after completing a high resolution esophageal manometry then brushing their teeth using Colgate toothpaste.

Treatment:

Other: Colgate

Diagnostic Test: High Resolution Esophageal Manometry (HREM)

Diagnostic Test: Esophageal String Test (EST)