A Study of Exercise Therapy in People With Solid Tumor Cancer

Memorial Sloan Kettering Cancer Center (MSK)

Status and phase: Withdrawn; Phase 1

Conditions: Solid Tumor Cancer

Treatments: Other: Exercise therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT06597786

24-232

Details and patient eligibility

About

The purpose of this study is to find out whether exercise therapy is an effective and safe treatment that causes few or mild side effects when done before standard surgery for solid tumor cancer. The researchers will also study whether the program is feasible (practical) by tracking how well participants follow the program.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with histologically confirmed (on preoperative biopsy), resectable, treatment naïve cancer of one of the following types: head and neck, lung, renal, liver, colorectal, gastric, ovarian, melanoma, pancreas, or breast cancer.
• Age ≥18 years.
• An interval of ≥3 weeks until planned surgical resection; surgery will not be delayed to accommodate the minimum length of exercise therapy intervention in any circumstance.
• Measurable disease based on standard of care radiology scans or confirmation by the surgeon.
• Body weight ≤ 385 lbs (≤ 174 kg)
• Non-exercisers, defined as ≤60 minutes of moderate or vigorous exercise/week based on self-report using a validated survey.
• Cleared for moderate-intensity exercise therapy using the Physical Activity Readiness Questionnaire (PAR-Q)+ with screening clearance provided at the discretion of the PI/exercise physiologist.
• Willingness to comply with all study-related procedures

Exclusion criteria

• Distant metastases.
• Receiving any form of antitumor therapy.
• Enrollment onto any other interventional investigational study except interventions determined by the PI not to confound the effect of exercise on study outcomes.
• Any other diagnosis of invasive cancer currently requiring active treatment.
• Any other condition (e.g., pregnancy) or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

Exercise therapy

Experimental group

Description:

Exercise therapy will comprise individualized treadmill walking delivered up to 5 times weekly (over a 7-day period) to achieve a weekly cumulative dose of 225 minutes per week. The minimum treatment period will be 3 weeks. Exercise therapy will be administered via a patient-centric, decentralized platform: Digital Platform for Exercise (DPEx). DPEx will permit all study procedures to be conducted remotely in patients' homes.

Treatment:

Other: Exercise therapy