GIC-102, Intravenous Allogeneic NK Cells, in Subjects With Advanced Solid Cancers and R/R Hematologic Malignancies

GI Cell

Status and phase: Enrolling; Phase 2; Phase 1

Conditions: Relapsed/Refractory Non-Hodgkin Lymphoma; Relapsed/Refractory Multiple Myeloma; Advanced Solid Tumors

Treatments: Drug: GIC-102

Study type: Interventional

Funder types: Industry

Identifiers

NCT05880043

GIC-102101

Details and patient eligibility

About

This is a first-in-human trial to investigate the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor effects of GIC-102 in patients with advanced solid tumors, relapsed/refractory non-hodgkin lymphoma, and multiple myeloma.

Full description

This is a first-in-human, open-label, non-randomized, dose-escalation and expansion phase 1/2a trial to determine the safety profile and identify the maximum tolerated dose of GIC-102 in patients with advanced solid tumors, relapsed/refractory non-hodgkin lymphoma, and multiple myeloma.

This study will comprise two phases.

• GIC-102 monotherapy dose escalation Phase
• GIC-102 monotherapy dose expansion phase

GIC-102 is an "off-the-shelf" allogeneic natural killer cells isolated from non-HLA-related healthy donor. Natural killer cells are innate immune cells that show strong cytolytic function against physiologically stressed cells such as tumor cells and virus infected cells.

Enrollment: 50 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. At least 19 years of age
2. Advanced solid tumors, relapsed/refractory non-hodgkin lymphoma, and multiple myeloma
3. At least one measurable or evaluable lesion
4. Eastern Cooperative Oncology Group performance status 0 or 1
5. A life expectancy of 12 weeks or more
6. Acceptable hematological function, kidney, and liver function
7. Subjects who sign on an informed consent form willingly

Exclusion criteria

1. Clinically significant cardiovascular disease within 24 weeks

2. Primary malignant tumor other than the indications for this study

3. The following diseases

   1. Severe infection or other uncontrolled active infectious disease requiring administration of systemic antibiotics or antivirals within 4 weeks
   2. The New York Heart Association class III/IV
   3. Active hepatitis B virus or hepatitis C virus infection
   4. Human immunodeficiency virus positive
   5. Clinically significant symptoms or uncontrolled central nervous system metastasis

4. Previously been diagnosed with immunodeficiency or need systemic corticosteroids or other systemic immunosuppressants within 2 weeks or require administration of systemic immunosuppressants during the study

5. Received chemotherapy other than pre-conditioning within 4 weeks

6. Underwent major surgery within 4 weeks prior or minor surgery within 2 weeks

7. Hypersensitivity reactions to the study drug or excipients

8. Hypersensitivity to cyclophosphamide or fludarabine

9. Have received allogeneic cell therapy within 6 months or autologous stem cell therapy within 4 weeks

10. Have previously received an allogeneic tissue/solid organ transplant

11. Have administered other investigational drug or applied other investigational medical device within 4 weeks

12. Pregnant or lactating female subjects

13. Male subjects who did not agree to use contraception or to maintain abstinence

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Dose escalation phase: GIC-102 monotherapy

Experimental group

Description:

* Low Dose level 1: 1 x 10\^9 cells * Mid Dose level 2: 3 x 10\^9 cells * High Dose level 3: 1 x 10\^10 cells

Treatment:

Drug: GIC-102

Drug: GIC-102

Dose expansion phase: GIC-102 monotherapy

Experimental group

Description:

- Dose level: RP2D

Treatment:

Drug: GIC-102

Drug: GIC-102