A Study of GRN163L With Paclitaxel and Bevacizumab to Treat Patients With Locally Recurrent Or Metastatic Breast Cancer

Geron

Status and phase

Completed

Phase 1

Conditions

Breast Cancer

Treatments

Drug: GRN163L

Study type

Interventional

Funder types

Industry

Identifiers

NCT00732056

GRN163L CP14A010

Details and patient eligibility

About

The purpose of this study is to determine the maximum tolerated dose (MTD) of GRN163L in combination with paclitaxel and bevacizumab in patients with locally recurrent or metastatic breast cancer (MBC)

Full description

GRN163L is a telomerase template antagonist with in vitro and in vivo activity in a variety of tumor model systems. Telomerase is an enzyme that is active primarily in tumor cells and is crucial for the indefinite growth of tumor cells. Inhibition of telomerase may result in antineoplastic effects.

Enrollment

24 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologically or cytologically confirmed adenocarcinoma of the breast with measurable locally recurrent or metastatic disease
May have had one prior non-taxane chemotherapy regimen for metastatic disease
If HER2 positive, must have had prior treatment with trastuzumab (Herceptin®)
If previously treated with an anthracycline, anthracenedione, or trastuzumab must be tested by MUGA scan or echocardiogram and have LVEF ≥ 50%
Must have recovered from most recent radiation treatment or surgical procedure
ECOG performance status of 0 or 1
Life expectancy ≥ 3 months

Exclusion criteria

Locally recurrent disease amenable to resection with curative intent
Prior adjuvant or neoadjuvant taxane chemotherapy within 12 months prior to first study drug administration
Investigational therapy within 4 weeks prior to first study drug administration
Prior hormonal therapy within 2 weeks prior to first study drug administration
Prior radiotherapy within 2 weeks prior to first study drug administration
Cytotoxic chemotherapy within 2 weeks prior to first study drug administration
Therapeutic anticoagulation or regular use of anti-platelet therapy within 2 weeks prior to first study drug administration NOTE: Low-dose anticoagulant therapy to maintain patency of a vascular access device is allowed.
Prolongation of PT or INR, aPTT > ULN, or fibrinogen < LLN
Active or chronically current bleeding (eg, active peptic ulcer)
Clinically significant cardiovascular or cerebrovascular disease including

Any history of:

Cerebrovascular disease including TIA, stroke or subarachnoid hemorrhage
Ischemic bowel

Within the last 12 months:

MI
Unstable angina
NYHA grade II or greater CHF
Grade 2 or greater peripheral vascular disease

Active at study entry:

Uncontrolled hypertension defined as SBP > 160 or DBP > 90
Uncontrolled or clinically significant arrhythmia
Clinically relevant active infection
Nonhealing wound or fracture
Serious co-morbid medical conditions, including cirrhosis and chronic obstructive or chronic restrictive pulmonary disease
Active autoimmune disease requiring immunosuppressive therapy
Known positive serology for HIV
Prior malignancy (within the last 3 years) except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, in situ breast cancer, or in situ prostate cancer, or other cancer for which the patient has been disease-free for at least 3 years
Any other severe, acute, or chronic medical or psychiatric condition, laboratory abnormality, or difficult complying with protocol requirements that may increase the risk associated with study participation or study drug administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the patient inappropriate for this study