A Study of Itraconazole in the Prevention of Histoplasmosis, a Fungal Infection, in HIV-Infected Patients

Janssen (J&J Innovative Medicine)

Status: Completed

Conditions: Histoplasmosis; HIV Infections

Treatments: Drug: Itraconazole

Study type: Interventional

Funder types: Industry

Identifiers

NCT00002438

MSG 28

235B

ITR-USA-73

Details and patient eligibility

About

To assess the safety and efficacy of itraconazole versus placebo for prevention of histoplasmosis in HIV-infected patients with CD4 counts < 150 cells/mm3 who reside where histoplasmosis is endemic. To assess the safety and efficacy of itraconazole for preventing other debilitating fungal infections, such as cryptococcosis, aspergillosis, recalcitrant oropharyngeal or vaginal candidiasis, and recurrent esophageal candidiasis.

Sex: All

Ages: 13+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Patients must have:

• HIV infection.
• Residence in an area endemic for H. capsulatum.
• Absolute CD4 count < 150 cells/mm3.
• No current or past active histoplasmosis.
• No other active fungal infection.
• Life expectancy of at least 1 year.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

• Life-threatening infection or malignancy other than cutaneous Kaposi's sarcoma.
• Inability to take oral medication.

Concurrent Medication:

Excluded:

• Systemically-active antifungals.
• Investigational drugs (expanded access drugs are acceptable).
• Rifampin.
• Rifabutin.
• Terfenadine.
• Astemizole.
• Phenobarbital.
• Phenytoin.
• Carbamazepine.
• H2 blockers.
• Omeprazole.
• Continual antacids.

Patients with the following prior conditions are excluded:

History of intolerance to imidazole or azole compounds.

Prior Medication:

Excluded within 1 month prior to study entry:

• Investigational drugs (expanded access drugs are acceptable).

Excluded within 15 days prior to study entry:

• Rifampin.
• Rifabutin.
• Terfenadine.
• Astemizole.
• Phenobarbital.
• Phenytoin.
• Carbamazepine.