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A Study of LY3025876 in Healthy Volunteers

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Lilly

Status and phase

Completed
Phase 1

Conditions

Healthy Volunteers

Treatments

Drug: LY3025876
Drug: Placebo

Study type

Interventional

Funder types

Industry

Identifiers

NCT01528124
14346
I6D-FW-SMRA (Other Identifier)

Details and patient eligibility

About

This trial is conducted in Singapore. The aim of this trial is to evaluate the safety and tolerability of the study drug in healthy people and investigate how much of the study drug gets into the blood stream and how long it takes the body to get rid of it. Information about any side effects that may occur will also be collected.

Enrollment

41 patients

Sex

All

Ages

21 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Must be either a healthy male or a healthy female who cannot become pregnant
  • Have a body mass index (BMI) of 18.5 to 40.0 kilograms per meter squared (kg/m^2), inclusive, at screening

Exclusion criteria

  • Are allergic to LY3025876 or related compounds
  • Have a history of significant disease that may affect the actions of drugs or may pose a risk when taking the study medication
  • Have a history of developing allergies, asthma, severe drug allergies (symptoms including, but not limited to, itching, red rashes, sores on the skin, scaling and shedding of skin), allergies or reactions to more than one drug, or have had bad reactions to skin creams containing corticosteroids. Corticosteroids are mainly used to control inflammation.

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

41 participants in 2 patient groups, including a placebo group

Placebo
Placebo Comparator group
Description:
0.9% sodium chloride given as a single subcutaneous injection
Treatment:
Drug: Placebo
LY3025876
Experimental group
Description:
Single escalating doses of LY3025876 given as subcutaneous injections
Treatment:
Drug: LY3025876

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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