A Study of LY3305677 in Healthy Participants

Lilly

Status and phase

Completed

Phase 1

Conditions

Healthy

Treatments

Drug: LY3305677

Drug: Placebo

Study type

Interventional

Funder types

Industry

Identifiers

16350

I8P-MC-OXAA (Other Identifier)

Details and patient eligibility

About

The purpose of this study is to evaluate the safety of LY3305677 and any side effects that might be associated with it.

This study will also look at how much LY3305677 gets into the blood stream, how long it takes the body to remove it.

This study involves a single dose of LY3305677 administered by subcutaneous injection (SC).

Participation in this study is expected to last up to 16 weeks.

Enrollment

66 patients

Sex

All

Ages

20 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Overtly healthy as determined by medical history and physical examination
Male participants: will agree to use a reliable method of birth control and will not donate sperm during the study and for at least 3 months following the last dose of the investigational product
Female participants: women not of child-bearing potential due to surgical sterilization confirmed by medical history or menopause
First generation Japanese participants or non-Japanese participants
Have a body weight of more than 50 kilograms (kg)

Exclusion criteria

Have participated within the last 3 months in a clinical trial involving an investigational product
Have known allergies to glucagon-like peptide-1 (GLP-1) analogs, or any components of the formulation, or history of significant atopy
Have an abnormality in the 12-lead electrocardiogram (ECG) at screening and/or Day -1
Have undergone any form of bariatric surgery
Have obvious clinical signs or symptoms of liver disease, acute or chronic hepatitis
Have a history of acute or chronic pancreatitis or elevation in serum lipase and/or amylase
Show evidence of human immunodeficiency virus (HIV) or Hepatitis B or C
Have used or intend to use medications that promote weight loss
Have donated blood of more than 500 milliliter (mL) within the last month
Currently smoke more than 10 cigarettes per day