A Study of LY3305677 in Participants With Type 2 Diabetes

Lilly

Status and phase

Completed

Phase 1

Conditions

Diabetes Mellitus, Type 2

Treatments

Drug: Placebo

Drug: LY3305677

Study type

Interventional

Funder types

Industry

Identifiers

NCT03928379

2018-004779-11 (EudraCT Number)

I8P-MC-OXAD (Other Identifier)

17011

Details and patient eligibility

About

The main purpose of this study is to learn more about the safety and side effects of LY3305677 when it is given as an injection just under the skin to participants with type 2 diabetes. The study will last about 20 weeks for each participant, not including screening.

Enrollment

24 patients

Sex

All

Ages

20 to 69 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Have Type II diabetes
Body mass index (BMI) of 25-40 kilograms per square meter (kg/m²), inclusive
Have a body weight of <150 kilograms (kg)
Have clinical lab test results within normal reference range for the population or investigator site, or results with acceptable deviations that are judged to be not clinically significant by the investigator; however, should have serum magnesium and potassium levels, along with lactate dehydrogenase, CK values within the normal range at screening and Day -2.

Exclusion criteria

Have Type 1 diabetes or latent autoimmune diabetes in adults
Have uncontrolled diabetes defined as an episode of ketoacidosis or hyperosmolar state requiring hospitalization for 6 months prior to screening
Have had an episode of severe hypoglycemia, defined by the occurrence of neuroglycopenic symptoms requiring the assistance of another person for recovery, within 6 months prior to Visit 1
Have an abnormal 12-lead electrocardiogram (ECG) at screening and/or Day -2 that, in the opinion of the investigator, increases the risks associated with participating in the study or may confound ECG data analysis
Have poorly controlled hypertension at screening; or a change in antihypertensive medication within 30 days of screening
Have an estimated glomerular filtration rate <45 milliliters per minute per 1.73 meters squared of body surface area (mL/min/1.73 m²)