A Study of MEMP1972A in the Prevention of Allergen-Induced Airway Obstruction in Patients With Mild Asthma (SOLARIO)

Genentech

Status and phase

Completed

Phase 2

Conditions

Asthma

Treatments

Drug: placebo

Drug: MEMP1972A

Study type

Interventional

Funder types

Industry

Identifiers

NCT01196039

MOP4843g

GA01332 (Other Identifier)

Details and patient eligibility

About

This Phase II, double-blind, placebo-controlled, randomized, parallel-group study is designed to evaluate the efficacy, safety and tolerability of MEMP1972A when administered to patients by intravenous (IV) infusion for the treatment of allergen-induced asthma.

Enrollment

29 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Mild, stable allergic asthma
History of episodic wheeze and shortness of breath
FEV1 at baseline >= 70% of the predicted value
Males or females who are surgically sterilized, post menopausal for the past year, or are using two acceptable methods of contraception against pregnancy through at least 5 months following the last administration of study drug
Documented PC20 value for prediction of the starting allergen concentration at screening
Positive skin prick test to common standard aeroallergens extracts
Positive allergen-induced early and late airway response

Exclusion criteria

A worsening of asthma within 6 weeks preceding Visit 1
Acute respiratory infection within 6 weeks preceding Visit 2 or any ongoing chronic infection
History of recurrent bacterial infection as an adult or history or presence of any chronic infectious condition
Risk of exposure, as determined by the investigator, to water-borne parasites or clinical diagnosis of parasitic infection that is untreated within 3 months prior to Visit 5
Lung disease other than mild allergic asthma
History of clinically significant hypotensive episodes or symptoms of fainting, dizziness, or lightheadedness
History or symptoms of cardiovascular disease
History or symptoms of significant neurologic disease
History of significant hepatic or renal impairment
Evidence of an active or suspected cancer or history of treatment for cancer
History or symptoms of clinically significant autoimmune disease
Any acquired or congenital immune deficiency
Confirmed positive test for HIV or hepatitis B or C
Concomitant disease or condition, which could interfere with the conduct of the study, or for which the treatment might interfere with the conduct of the study, or which would, in the opinion of the investigator, poses an unacceptable risk to the patients in this study
History of serious adverse reaction or hypersensitivity to any drug
Clinically significant abnormal chest radiograph within the last 12 months
Pregnancy or lactation or positive serum pregnancy test at screening
Use of corticosteroids, immunosuppressives, anticoagulants, or any medications that may interact with study drug within 4 weeks prior to Visit 2
Chronic use of any other medication for treatment of allergic lung disease other than short-acting Î²2-agonists or ipratropium bromide
Use of cromoglycate, nedocromil, leukotriene receptor antagonists, and inhibitors of 5-lipoxygenase are not permitted within 4 weeks prior to Visit 2
Allergen or peptide immunotherapy within 6 months prior to study treatment
Participation in any other investigational drug study within the preceding 30 days or 5 half-lives of that drug, whichever is longer at the time of Visit 2
Current (or history of) treatment with a monoclonal antibody or chimeric biomolecule within the past 5 months, including omalizumab, at the time of Visit 2
Use of statins are not permitted within 4 weeks prior to Visit 2
Received live or attenuated vaccine within 30 days prior to Visit 5
Regular use of tobacco products of any kind or within the previous 6 months, or smoking history > 10 pack-years
History of drug or alcohol abuse
Donation of blood over 500 mL within 3 months prior to Visit 5
Unwillingness or inability to comply with the study protocol for any other reason