A Study of Metabolic Agents Following Brain Radiation

Mayo Clinic

Status: Invitation-only

Conditions: CNS Malignancy

Treatments: Diagnostic Test: Chemical Exchange Saturation Transfer Magnetic Resonance Imaging; Diagnostic Test: FDG Positron Emission Tomography

Study type: Observational

Funder types: Other

Identifiers

NCT06150547

22-009871

Details and patient eligibility

About

This study is being done to determine if CEST magnetic resonance imaging (MRI) and FDG PET are feasible techniques to detect metabolic differences between tumor and brain in patients with a brain tumor.

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Radiographic evidence or histopathologic confirmation of CNS malignancy, with or without prior resection.
• Provide written informed consent for the current study.
• Willing to undergo at least one MRI (and possibly more at PI discretion) with proton and/or phosphorus magnetic resonance spectroscopy analysis.

Exclusion criteria

• Vulnerable populations: pregnant or nursing women (Arm B exempt), prisoners, mentally handicapped.
• Cardiac pacemaker or artificial heart valve
• Metal plate, pin, or other metallic implant
• Intrauterine device, such as Copper-7 IUD
• Insulin or other drug pump
• Non-titanium aneurysm clips
• Previous gunshot wound
• Cochlear implant or other hearing device
• Employment history as a metalworker (had metal in eye)
• Permanent (tattoo) eye-liner
• For FDG-PET specifically: Fasting blood sugar level greater than 200mg/dl

Trial design

10 participants in 1 patient group

Central Nervous System Malignant Tumor

Description:

Subjects may receive up to two CEST MRI's tests and/or up to two FDG PET. The physician will determine which test is appropriate based on your tumor type, past treatment history and research question. Tests will be completed at initial baseline visit and at least one other MRI/PET after the initial baseline, up to a maximum of four scans. Additionally, patients undergo finger-poke blood collection prior to receiving FDG on study.

Treatment:

Diagnostic Test: FDG Positron Emission Tomography

Diagnostic Test: Chemical Exchange Saturation Transfer Magnetic Resonance Imaging