A Study of Mezigdomide in Healthy Participants and Participants With Hepatic Impairment

Bristol-Myers Squibb (BMS)

Status and phase: Completed; Phase 1

Conditions: Hepatic Impairment

Treatments: Drug: Mezigdomide

Study type: Interventional

Funder types: Industry

Identifiers

NCT05707390

CA057-1010

Details and patient eligibility

About

The aim of this study is to measure the concentration levels of mezigdomide in the blood of participants with mild, moderate, and severe hepatic impairment, and in matched healthy control participants with normal hepatic function.

Enrollment: 32 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Hepatic Impaired Participants:

• Participants have mild, moderate, or severe hepatic impairment or cirrhosis due to chronic hepatic disease and/or prior alcohol use.
• Participants have mild (Group A), moderate (Group B), or severe (Group C) hepatic impairment as defined by Child-Pugh Score.

Matched Healthy Participants:

• Participant must be free of any clinically significant disease that would interfere with the study evaluations.
• Participant must have liver-related laboratory test results within the respective reference ranges or with clinically insignificant excursions therefrom as agreed by the investigator.

Exclusion criteria

All Participants:

• History of chronic pruritus or dermatologic syndromes that may be confounded with reactions to mezigdomide.
• Contraindication or intolerance to first-generation antihistamine medications.

Hepatic Impaired Participants:

-Clinical laboratory test results:

• Platelet count lower than 30,000/microliter (μL) at screening or Day -1.
• Absolute neutrophil counts lower than 1,500/μL at screening or Day -1.

Matched Healthy Participants:

-History of or suspected benign ethnic neutropenia.

Other protocol-defined inclusion/exclusion criteria apply

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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32 participants in 4 patient groups

Mild hepatic impairment

Experimental group

Treatment:

Drug: Mezigdomide

Moderate hepatic impairment

Experimental group

Treatment:

Drug: Mezigdomide

Severe hepatic impairment

Experimental group

Treatment:

Drug: Mezigdomide

Healthy participants

Experimental group

Treatment:

Drug: Mezigdomide